The efficacy of diuretics in complex treatment of patients with hypertension according to the Gly460Trp polymorphism of the α-adducin gene

The aim of the study was to investigate effect thiazide diuretics on blood pressure (BP) depending Gly460Trp ADD1 gene polymorphism in arterial hypertension (AH) patients Ukrainian population order predict their individual treatment efficacy. Material and methods. included 232 persons: 120 with verified stage II AH 112 healthy individuals. Restriction fragment length polymerase chain reaction (PCR-RFLP) used detect genotype (the Gly460Trp-polymorphic locus gene). received standard therapy, which ACE inhibitor – ramipril 5 mg, calcium channel antagonist amlodipine statin atorvastatin 20 acetylsalicylic acid 75 mg. were randomized into two groups: group I (60 persons) additionally taking 1.5 mg indapamide retard 25 hydrochlorothiazide. dynamic reduction has been assessed every 4 weeks for 2 months. Results. Among AH, 91 persons (75.8 %) homozygous G allele (GG), 26 (21.7 heterozygous (GT) 3 (2.5 T (TT), while frequency 0.87, 0.13. 98 individuals (87.5 allele, 13 (11.6 heterozygous, 1 person (0.9 allele. carrier alleles 0.93 0.07, respectively. Allelic distribution indicated predominance carriers by among population, regardless whether symptoms present. It is noteworthy that number times large symptomatic than In hypotensive efficacy almost higher antihypertensive hydrochlorothiazide GT TT genotypes greater GG presence G460T genotype. Conclusions. indicates are accumulation polymorphic marker α-adducin more Patients carrying demonstrate compared